Mastering variation: variance components and personalised medicine

Mastering variation: variance components and personalised medicine

Various sources of variation in observed response in clinical trials and clinical practice are considered, and ways in which the corresponding components of variation might be estimated are discussed. Although the issues have been generally well-covered in the statistical literature, they seem to be poorly understood in the medical literature and even the statistical literature occasionally sho...

Personalised Medicine

In recent years we have seen the emergence of “personalised medicine.” This development can be seen as the logical product of reductionism in medical science in which disease is increasingly understood in molecular terms. Personalised medicine has flourished as a consequence of the application of neoliberal principles to health care, whereby a commercial and social need for personalised medicin...

Variance Components

Variance Components

Definition: Translational and Personalised Medicine, Biomarkers, Pharmacodynamics